phdindustrialengineering

SERGIO BERNARDINI

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Personal Information

Name

SERGIO BERNARDINI

Nationality

Italian

Date of birth

2 Marzo, 1961

Contact Details

Address

Departmemnt of Experimental Medicine Rome Tor Vergata University Via Montpellier 1, 00133 Rome, Italy

Office Location

Tor Vergata Hospital, Viale Oxford 81, 1st floor, Clinical Laboratory , room 14

Phone

39 06 20902262

Mobile

39 3804399292

Email

Languages

Native Language

Italian

Others

English
Reading skills: excellent
Writing skills: excellent
Verbal skills: excellent

Curriculum

Current Position

Full professor of Clinical Biochemistry and Clinical Molecular Biology
Rome “Tor Vergata” University – Department of “Experimental Medicine”.
Head Physician Laboratory Medicine Tor Vergata Hospital

Education

Master Degree in Medicine at the University of Rome “La Sapienza”
Specialization in Pediatrics University of Rome “La Sapienza”
PhD in Pediatric Sciences University of Rome “Tor Vergata”
Specialization in Clinical Biochemistry University of Camerino

Teaching

Clinical Biochemistry and Clinical Molecular Biology: degree STS, TLBM, Medicine, Sport Sciences

SSD BIO/12

Research Activities

From 1984 to 1991 my research focused on paediatric endocrinology with particular interest in growth hormone and insulin like growth factors and their binding proteins. From 1991 to 1998 my studies concentrated on the role of the molecules described above and on retinoids in the apoptotic pathways in oncology, in particular neuroblastoma.
Since 1998 I have focused on Glutathione transferases, a family of enzymes involved in cell detoxification and in the control of the programmed cell death. This work has concentrated on the role of those enzymes in the mechanisms responsible for drug resistance depending on changes in the redox status of the cell. As part of this research I have set up and managed a cell and molecular biology laboratory able to perform qRT-PCR and microarray for differential gene expression as well as some applications in Proteomics.
Since 2003 I have collaborated in the application of molecular biology methods and proteomics techniques in research applied to neurodegenerative diseases, oncology and pharmacogenetics.
Since 2009 I have collaborated in the application of molecular biology and biochemical methods to monitoring of sport training and performance

Publications (last 5 years)

Publications (last 5 years)

Pubblications 2016-2020

  1. Liguori C, Placidi F, Izzi F, Nuccetelli M, Bernardini S, Sarpa MG, Cum F, Marciani MG, Mercuri NB, Romigi A. Beta-amyloid and phosphorylated tau metabolism changes in narcolepsy over time.
    Sleep Breath. 2016 Mar;20(1):277-83
  2. Ialongo C, Pieri M, Bernardini S.
    Artificial Neural Network for Total Laboratory Automation to Improve the Management of Sample Dilution: Smart Automation for Clinical Laboratory Timeliness.
    J Lab Autom. 2016 Mar 8. pii: 2211068216636635. [Epub ahead of print] PubMed PMID: 26956577.
  3. Ialongo C, Bernardini S.
    Phlebotomy, a bridge between laboratory and patient.
    Biochemia Medica 2016; 26:13-33.
  4. Ialongo C, Bernardini S. Timeliness “at a glance”: assessing the turnaround time through the six sigma metrics.
    Biochemia Medica 2016;26:98-102.
  5. Ialongo C, Marano M, Bertucci PF, Marsella LT, De Zorzi A, Bernardini S.
    The importance of the toxicological analysis in newborns: clearing the case of a tetralogy of Fallot with a paradoxical reaction to 1-hydroxymidazolam.
    Journal of Pediatric and Neonatal Individualized Medicine 2016;5:e1-7.
  6. Barbetti F, Colombo C, Haataja L, Cras-Méneur C, Bernardini S, Arvan P.
    Hyperglucagonemia in an animal model of insulin-deficinet diabetes: what therapy can improve it?
    Clinical Diabetes And endocrinology 2016; 2:11
  7. Fintini D, Cappa M, Brufani C, Bernardini S, Barbetti F.
    Prevalence of elevated 1-h plasma glucose and its associations in obese youth. Diabetes Res
    Clin Pract. 2016 Jun;116:202-4.
  8. Bizzarri C, Massimi A, Federici L, Cualbu A, Loche S, Bellincampi L, Bernardini S, Cappa M, Porzio O. A . New Homozygous Frameshift Mutation in the HSD3B2 Gene in an Apparently Nonconsanguineous Italian Family.
    Horm Res Paediatr. 2016 Apr 16. [Epub ahead of print] PubMed PMID: 27082427.
  9. Liguori C, Nuccetelli M, Izzi F, Sancesario G, Romigi A, Martorana A, Amoroso C, Bernardini S, Marciani MG, Mercuri NB, Placidi F.
    Rapid eye movement sleep disruption and sleep fragmentation are associated with increased orexin-A cerebrospinal-fluid levels in mild cognitive impairment due to Alzheimer’s disease.
    Neurobiol Aging. 2016 Apr;40:120-6.
  10. Pieri M, Pignalosa S, Dinallo V, Crisanti A, Casalino P, Bernardini S, Dessi
    M, Rossella Z. Free light chains nephelometric assay: human urine stability in different storage conditions.
    Clin Chem Lab Med. 2016 Feb 25. pii: /j/cclm.ahead-of-print/cclm-2015-1174/cclm-2015-1174.xml. doi: 10.1515/cclm-2015-1174. [Epub ahead of print] PubMed PMID: 26913458.
  11. Ialongo C, Porzio O, Giambini I, Bernardini S.
    Total Automation for the Core Laboratory: Improving the Turnaround Time Helps to Reduce the Volume of Ordered STAT Tests.
    J Lab Autom. 2016 J Lab Autom. Jun;21(3):451-8.
  12. Godos J, Zappalà G, Bernardini S, Giambini I, Bes-Rastrollo M, Martinez-Gonzalez M.
    Adherence to the Mediterranean diet is inversely associated with metabolic syndrome occurrence: a meta-analysis of observational studies.
    Int J Food Sci Nutr. 2016 Aug 25:1-11. [Epub ahead of print] PubMed PMID: 27557591.
  13. Onorati M, Sancesario G, Pastore D, Bernardini S, Carrión JE, Carosi M, Vignoli L, Lauro D, Gentile G.
    Plasma concentrations of progesterone andestradiol and the relation to reproduction in Galápagos land iguanas, Conolophus marthae and C. subcristatus (Squamata, Iguanidae).
    Anim Reprod Sci. 2016 Sep;172:105-13. doi: 10.1016/j.anireprosci.2016.07.007. Epub 2016 Jul 15. PubMed PMID: 27449407.
  14. Roselli M, Ferroni P, Riondino S, Mariotti S, Portarena I, Alessandroni J, Ialongo C, Massoud R, Costarelli L, Cavaliere F, Bernardini S, Guadagni F. Functional impairment of activated protein C in breast cancer – relationship to survival outcomes.
    Am J Cancer Res. 2016 Jun 1;6(6):1450-7. eCollection 2016. PubMed PMID: 27429857; PubMed Central PMCID: PMC4937746.
  15. Ialongo C, Pieri M, Bernardini S. Smart management of sample dilution using an artificial neural network to achieve streamlined processes and saving resources: the automated nephelometric testing of serum free light chain as case study.
    Clin Chem Lab Med. 2016 Jul 12. pii: /j/cclm.ahead-of-print/cclm-2016-0263/cclm-2016-0263.xml. doi:10.1515/cclm-2016-0263. [Epub ahead of print] PubMed PMID: 27404901.
  16. Petropoulos K, Piermarini S, bernardinis S, Palleschi G, Moscone D.
    Development of a disposable biosensor for lactate monitoring in saliva.
    Sensor and Actuators B: Chemical 2016;237:8-15.
  17. Pieri M, Pignalosa S, Zenobi R, Callà C, Martino FG, Menichella G, Mancina F, Moscato U, Nocca G, Khashoggi H, Bernardini S, Dessì M, Di Daniele N. Reference intervals for HbA1c partitioned for gender and age: a multicenter study.
    Acta Diabetol. 2016 Oct 22. [Epub ahead of print] PubMed PMID: 27771764.
  18. De Lorenzo A, Bernardini S, Gualtieri P, Cabibbo A, Perrone MA, Giambini I, Di Renzo L. Mediterranean meal versus Western meal effects on postprandial ox-LDL, oxidative and inflammatory gene expression in healthy subjects: a randomized controlled trial for nutrigenomic approach in cardiometabolic risk.
    Acta Diabetol. 2016 Oct 5. [Epub ahead of print] PubMed PMID: 27709360.
  19. Ticconi C, Pietropolli A, Borelli B, Bruno V, Piccione E, Bernardini S, Di
    Simone N. Antinuclear autoantibodies and pregnancy outcome in women with
    unexplained recurrent miscarriage.
    Am J Reprod Immunol. 2016 Nov;76(5):396-399. doi: 10.1111/aji.12560. PubMed PMID: 27616598.
  20. Campione E, Botta A, Di Prete M, Rastelli E, Gibellini M, Petrucci A, Bernardini S, Novelli G, Bianchi L, Orlandi A, Massa R, Terracciano C. Cutaneous features of myotonic dystrophy types 1 and 2: Implication of premature aging and vitamin D homeostasis.
    Neuromuscul Disord. 2016 Nov 16. pii: S0960-8966(16)30856-2. doi: 10.1016/j.nmd.2016.11.004. [Epub ahead of print] PubMed PMID: 28065683.
  21. Sancesario GM, Toniolo S, Chiasserini D, Di Santo SG, Zegeer J, Bernardi G; for SIBioC-Study Group of Clinical Biochemistry of Biological Fluids other than Blood., Musicco M; for SINdem-ITALPLANED., Caltagirone C, Parnetti L, Bernardini S. The Clinical Use of Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease Diagnosis: The Italian Selfie.
    J Alzheimers Dis. 2017;55(4):1659-1666. doi: 10.3233/JAD-160975. PubMed PMID: 27911328.
  22. Merra G, Gratteri S, De Lorenzo A, Barrucco S, Perrone MA, Avolio E, Bernardini S, Marchetti M, Di Renzo L. Effects of very-low-calorie diet on body composition, metabolic state, and genes expression: a randomized double-blind placebo-controlled trial.
    Eur Rev Med Pharmacol Sci. 2017 Jan;21(2):329-345.
  23. Martello S, Pieri M, Ialongo C, Pignalosa S, Noce G, Vernich F, Russo C, Mineo F, Bernardini S, Marsella LT. Levamisole in Illicit Trafficking Cocaine Seized: A One-Year Study.
    J Psychoactive Drugs. 2017 Aug 16:1-5. doi: 10.1080/02791072.2017.1361558. [Epub ahead of print] PubMed PMID: 28813206.
  24. Onorati M, Sancesario G, Pastore D, Bernardini S, Cruz M, Carrión JE, Carosi M, Vignoli L, Lauro D, Gentile G. Effects of parasitic infection and reproduction on corticosterone plasma levels in Galápagos land iguanas, Conolophus marthae and C. subcristatus.
    Ecol Evol. 2017 Jul 5;7(15):6046-6055. doi: 10.1002/ece3.3077.eCollection 2017 Aug. PubMed PMID: 28808564; PubMed Central PMCID: PMC5551272.
  25. Ialongo C, Mozzi AF, Bernardini S. An LC-MS Assay with Isocratic Separation and On-line Solid Phase Extraction to Improve the Routine Therapeutic Drug Monitoring of Busulfan in Plasma. J Med Biochem. 2017 Apr 22;36(2):113-121. doi: 10.1515/jomb-2016-0031. eCollection 2017 Apr. PubMed PMID: 28680354;
  26. Pieri M, Storto M, Pignalosa S, Zenobi R, Buttari F, Bernardini S, Centonze D, Dessi M. KFLC Index utility in multiple sclerosis diagnosis: Further confirmation.
    J Neuroimmunol. 2017 Aug 15;309:31-33. doi: 10.1016/j.jneuroim.2017.05.007. Epub 2017 May 12. PubMed PMID: 28601282.
  27. Cento V, Nguyen THT, Di Carlo D, Biliotti E, Gianserra L, Lenci I, Di Paolo D, Calvaruso V, Teti E, Cerrone M, Romagnoli D, Melis M, Danieli E, Menzaghi B, Polilli E, Siciliano M, Nicolini LA, Di Biagio A, Magni CF, Bolis M, Antonucci FP, Di Maio VC, Alfieri R, Sarmati L, Casalino P, Bernardini S, Micheli V, Rizzardini G, Parruti G, Quirino T, Puoti M, Babudieri S, D’Arminio Monforte A,Andreoni M, Craxì A, Angelico M, Pasquazzi C, Taliani G, Guedj J, Perno CF, Ceccherini-Silberstein F. Improvement of ALT decay kinetics by all-oral HCVtreatment: Role of NS5A inhibitors and differences with IFN-based regimens.
    PLoS One. 2017 May 18;12(5):e0177352. doi: 10.1371/journal.pone.0177352. eCollection
    2017. PubMed PMID: 28545127; PubMed Central PMCID: PMC5436665.
  28. Colica C, Merra G, Gasbarrini A, De Lorenzo A, Cioccoloni G, Gualtieri P, Perrone MA, Bernardini S, Bernardo V, Di Renzo L, Marchetti M. Efficacy and safety of very-low-calorie ketogenic diet: a double blind randomized crossover study.
    Eur Rev Med Pharmacol Sci. 2017 May;21(9):2274-2289. PubMed PMID: 28537652.
  29. Liguori C, Chiaravalloti A, Nuccetelli M, Izzi F, Sancesario G, Cimini A, Bernardini S, Schillaci O, Mercuri NB, Fabio P. Hypothalamic dysfunction is related to sleep impairment and CSF biomarkers in Alzheimer’s disease.
    J Neurol. 2017 Sep 12. doi: 10.1007/s00415-017-8613-x. [Epub ahead of print] PubMed PMID: 28900724.
  30. De Stefano A, Mannucci L, Massoud R, Bernardini S, Cortese C. Performancecharacteristics of lipoprotein-associated phospholipase A2 activity assay on the Dimension Vista analyser and preliminary study of a healthy Italian population.
    Biochem Med (Zagreb). 2017 Oct 15;27(3):030701. doi: 10.11613/BM.2017.030701. Epub 2017 Aug 28. PubMed PMID: 28900364; PubMed Central PMCID: PMC5575650.
  31. Liguori C, Romigi A, Izzi F, Placidi F, Nuccetelli M, Cordella A, Bernardini
    S, Biagio MN. Complement system dysregulation in patients affected by Idiopathic Generalized Epilepsy and the effect of antiepileptic treatment.
    Epilepsy Res. 2017 Sep 21;137:107-111. PubMed PMID: 28985614.
  32. Ialongo C, Bernardini S. Validation of the Six Sigma Z-score for the quality assessment of clinical laboratory timeliness.
    Clin Chem Lab Med. 2017 Oct 17.doi: 10.1515/cclm-2017-0642. [Epub ahead of print] PubMed PMID: 29040063.
  33. Liguori C, Chiaravalloti A, Izzi F, Nuccetelli M, Bernardini S, Schillaci O, Mercuri NB, Placidi F. Sleep apnoeas may represent a reversible risk factor for amyloid-β pathology.
    Brain. 2017 Oct 25. doi: 10.1093/brain/awx281. [Epub ahead of print] PubMed PMID: 29077794.
  34. Pascarella A, Terracciano C, Farina O, Lombardi L, Esposito T, Napolitano F, Franzese G, Panella G, Tuccillo F, la Marca G, Bernardini S, Boffo S, Giordano A, Melone MAB, Di Iorio G, Sampaolo S.
    Vacuolated PAS-positive lymphocytes as an hallmark of Pompe disease and other myopathies related to impaired autophagy.
    J Cell Physiol. 2017 Dec 7. doi: 10.1002/jcp.26365.
  35. Legramante JM, Mastropasqua M, Susi B, Porzio O, Mazza M, Miranda Agrippino G, D Agostini C, Brandi A, Giovagnoli G, Di Lecce VN, Bernardini S, Minieri M. Prognostic performance of MR-pro-adrenomedullin in patients with community acquired pneumonia in the Emergency Department compared to clinical severity scores PSI and CURB.
    PLoS One. 2017 Nov 21;12(11):e0187702.
  36. Ialongo C, Bernardini S. Validation of the Six Sigma Z-score for the quality assessment of clinical laboratory timeliness.
    Clin Chem Lab Med. 2018 Mar 28;56(4):595-601. doi: 10.1515/cclm-2017-0642
  37. Sancesario GM, Nuccetelli M, Cerri A, Zegeer J, Severini C, Ciotti MT, Pieri M, Martorana A, Caltagirone C, Nistico R, Bernardini S. Bromelain degrades Aβ1-42 monomers and soluble aggregates: an in vitro study in cerebrospinal fluid of Alzheimer’s disease patients.
    Curr Alzheimer Res. 2018;15(7):628-636. doi: 10.2174/1567205015666180123124851.
  38. Pascarella A, Terracciano C, Farina O, Lombardi L, Esposito T, Napolitano F, Franzese G, Panella G, Tuccillo F, la Marca G, Bernardini S, Boffo S, Giordano A, Melone MAB, Di Iorio G, Sampaolo S.
    Vacuolated PAS-positive lymphocytes as an hallmark of Pompe disease and other myopathies related to impaired autophagy.
    J Cell Physiol. 2018 Aug;233(8):5829-5837. doi: 10.1002/jcp.26365. Epub 2018 Feb 22.
  39. Innaurato S, Brierley GV, Grasso V, Massimi A, Gaudino R, Sileno S, Bernardini S, Semple R, Barbetti F. Severe insulin resistance in disguise: A familial case of reactive hypoglycemia associated with a novel heterozygous INSR mutation.
    Pediatr Diabetes. 2018 Jun;19(4):670-674. doi: 10.1111/pedi.12632. Epub 2018 Feb 7.
  40. Terrinoni A, Didona B, Caporali S, Chillemi G, Lo Surdo A, Paradisi M, Annichiarico-Petruzzelli M, Candi E, Bernardini S, Melino G. Role of the keratin 1 and keratin 10 tails in the pathogenesis of ichthyosis hystrix of Curth Macklin.
    PLoS One. 2018 Apr 24;13(4):e0195792. doi: 10.1371/journal.pone.0195792. eCollection 2018. PubMed PMID: 29689068; PubMed Central PMCID: PMC5918167.
  41. Terracciano C, Farina O, Esposito T, Lombardi L, Napolitano F, De Blasiis P,Ciccone G, Todisco V, Tuccillo F, Bernardini S, Di Iorio G, Melone MAB, Sampaolo S. Successful long-term therapy with flecainide in a family with paramyotonia congenita.
    J Neurol Neurosurg Psychiatry. 2018 Feb 27. pii: jnnp-2017-317615. doi: 10.1136/jnnp-2017-317615. [Epub ahead of print] PubMed PMID: 29487168.
  42. Khasoggi H, Pignalosa S, Russo C, Pieri M, Bernardini S. New HPLC instrument performance evaluation in HbA1c determination and comparison with capillary electrophoresis. Scandinavian Journal of Clinical and Laboratory Investigation 2018 DOI: 10.1080/00365513.2018.1487072
  43. Liguori C, Mercuri NB, Nuccetelli M, Izzi F, Bernardini S, Placidi F. Cerebrospinal Fluid Orexin Levels and Nocturnal Sleep Disruption in Alzheimer’s Disease Patients Showing Neuropsychiatric Symptoms. J Alzheimers Dis. 2018;66(3):993-999. doi: 10.3233/JAD-180769. PubMed PMID: 30372684.
  44. Schirinzi T, Sancesario GM, Di Lazzaro G, Biticchi B, Colona VL, Mercuri NB, Bernardini S, Pisani A. CSF α-synuclein inversely correlates with non-motor symptoms in a cohort of PD patients. Parkinsonism Relat Disord. 2018 Oct 15. pii: S1353-8020(18)30452-8. doi: 10.1016/j.parkreldis.2018.10.018. [Epub ahead of print] PubMed PMID: 30348495.
  45. Sancesario GM, Bernardini S. Diagnosis of neurodegenerative dementia: where do we stand, now? Ann Transl Med. 2018 Sep;6(17):340. doi: 10.21037/atm.2018.08.04. Review. PubMed PMID: 30306079; PubMed Central PMCID: PMC6174181.
  46. Mazzeo M, Di Raimondo C, Gurnari C, Rapanotti MC, Giunta A, Franceschini L, Rizzo M, Minieri M, Provenzano I, Bernardini S, Cantonetti M, Bianchi L. Early detection of IgH monoclonal rearrangenent in follicular spicules of the nose preceding multiple myeloma diagnosis. Case report and review of the literature. G.Ital Dermatol Venereol. 2018 Sep 20. doi: 10.23736/S0392-0488.18.06016-9. [Epub ahead of print] PubMed PMID: 30249084
  47. Pieri M, Zenobi R, Morello M, Storto M, Buttari F, Centonze D, Bernardini S, Dessi M. Multiple Sclerosis: kFLC index values related to gender. Mult Scler Relat Disord. 2018 Aug 30;26:58-60. doi: 10.1016/j.msard.2018.08.018. [Epub ahead of print] PubMed PMID: 30223231
  48. Mion MM, Bragato G, Zaninotto M, Alessandroni J, Bernardini S, Plebani M. Analytical performance evaluation of the new GEM(®) Premier™ 5000 analyzer in comparison to the GEM(®) Premier™ 4000 and the RapidPoint(®) 405 systems. Clin Chim Acta. 2018 Nov;486:313-319. doi: 10.1016/j.cca.2018.08.019. Epub 2018 Aug. PubMed PMID: 30118673.
  49. Perrone MA, Babu Dasari J, Intorcia A, Morgagni R, Sergi D, Battaini F, De Lorenzo A, Bernardini S, Merra G, Romeo F. Efficacy and safety of dronedarone in patients with amiodarone-induced hyperthyroidism: a clinical study.
    Eur Rev Med Pharmacol Sci. 2018 Dec;22(23):8502-8508. doi: 10.26355/eurrev_201812_16551.
    PubMed PMID: 30556893.
  50. Tripodi A, Santoro RC, Testa S, Molinari AC, Bernardini S, Golato M, Lippi G, Ageno W, Santagostino E. Position paper on laboratory testing for patients with haemophilia. A consensus document from SISET, AICE, SIBioC and SIPMeL.
    Blood Transfus. 2019 Feb 4:1-7. doi: 10.2450/2019.0241-18. [Epub ahead of print] PubMed PMID: 30747702.
  51. Alwardat M, Schirinzi T, Di Lazzaro G, Sancesario GM, Franco D, Imbriani P, Sinibaldi Salimei P, Bernardini S, Mercuri NB, Pisani A. Association between physical activity and dementia’s risk factors in patients with Parkinson’s disease.
    J Neural Transm (Vienna). 2019 Feb 12. doi: 10.1007/s00702-019-01979-0. [Epub ahead of print] PubMed PMID: 30746564.
  52. Saeed K, Wilson DC, Bloos F, Schuetz P, van der Does Y, Melander O, Hausfater P, Legramante JM, Claessens YE, Amin D, Rosenqvist M, White G, Mueller B, Limper M, Callejo CC, Brandi A, Macchi MA, Cortes N, Kutz A, Patka P, Yañez MC, Bernardini S, Beau N, Dryden M, van Gorp ECM, Minieri M, Chan L, Rood PPM, Del Castillo JG. The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study.
    Crit Care. 2019 Feb 8;23(1):40. doi: 10.1186/s13054-019-2329-5. PubMed PMID: 30736862; PubMed Central PMCID: PMC6368690.
  53. Terrinoni A, Calabrese C, Basso D, Aita A, Caporali S, Plebani M, Bernardini S. The circulating miRNAs as diagnostic and prognostic markers.
    Clin Chem Lab Med. 2018 Dec 20. pii: /j/cclm.ahead-of-print/cclm-2018-0838/cclm-2018-0838.xml. doi: 10.1515/cclm-2018-0838. [Epub ahead of print] Review. PubMed PMID: 30838832.
  54. Clerico A, Ripoli A, Masotti S, Musetti V, Aloe R, Dipalo M, Rizzardi S, Dittadi R, Carrozza C, Storti S, Belloni L, Perrone M, Fasano T, Canovi S, Correale M, Prontera C, Guiotto C, Cosseddu D, Migliard M, Bernardini S.
    Evaluation of 99th percentile and reference change values of a high-sensitivity cTnI method: A multicenter study.
    Clin Chim Acta. 2019 Jun;493:156-161 doi: 10.1016/j.cca.2019.02.029. [Epub ahead of print] PubMed PMID: 30826369.
  55. Liguori C, Mercuri NB, Nuccetelli M, Izzi F, Cordella A, Bernardini S, Placidi F. Obstructive sleep apnea may induce orexinergic system and cerebral β-amyloid metabolism dysregulation: is it a further proof for Alzheimer’s disease risk?
    Sleep Med. 2019 Jan 11. pii: S1389-9457(18)30829-3. doi: 10.1016/j.sleep.2019.01.003. [Epub ahead of print] PubMed PMID: 30799255.
  56. Clerico A, Masotti S, Musetti V, Ripoli A, Aloe R, Di Pietro M, Rizzardi S, Dittadi R, Carrozza C, Belloni L, Perrone M, Fasano T, Simone C, de Santis A, Prontera C, Guiotto C, Cosseddu D, Migliardi M, Bernardini S. Evaluation of 99th percentile and reference change values of the hs-cTnI method using ADVIA Centaur XTP platform: A multicenter study.
    Clin Chim Acta. 2019 Apr 9. pii: S0009-8981(19)31797-8. doi: 10.1016/j.cca.2019.04.056. [Epub ahead of print] PubMed PMID: 30978328.
  57. Ialongo C, Bernardini S. Total laboratory automation has the potential to be the field of application of artificial intelligence: the cyber-physical system and “Automation 4.0”.
    Clin Chem Lab Med. 2019 Apr 8. pii: /j/cclm.ahead-of-print/cclm-2019-0226/cclm-2019-0226.xml. doi: 10.1515/cclm-2019-0226. [Epub ahead of print] PubMed PMID: 30956229.
  58. Clerico A, Ripoli A, Zaninotto M, Masotti S, Musetti V, Ciaccio M, Aloe R, Rizzardi S, Dittadi R, Carrozza C, Fasano T, Perrone M, de Santis A, Prontera C, Riggio D, Guiotto C, Migliardi M, Bernardini S, Plebani M. Head-to-head comparison of plasma cTnI concentration values measured with three high-sensitivity methods in a large Italian population of healthy volunteers and
    patients admitted to emergency department with acute coronary syndrome: A multi-center study. Clin Chim Acta. 2019 Jun 12. pii: S0009-8981(19)31904-7. doi: 10.1016/j.cca.2019.06.012. [Epub ahead of print] PubMed PMID: 31201817.
  59. Fenouil T, Fourier A, Quadrio I, Streichenberger N, Bernardini S, Zima T,Perret-Liaudet A, Meyronet D. The standardization of cerebrospinal fluid markers and neuropathological diagnoses brings to light the frequent complexity of concomitant pathology in Alzheimer’s disease: The next challenge for biochemical markers?
    Clin Biochem. 2019 Jun 10. pii: S0009-9120(19)30345-5. doi: 10.1016/j.clinbiochem.2019.06.004. [Epub ahead of print] Review. PubMed PMID: 31194969.
  60. Palombo R, Caporali S, Falconi M, Iacovelli F, Morozzo Della Rocca B, Lo Surdo A, Campione E, Candi E, Melino G, Bernardini S, Terrinoni A. Luteolin-7-O-β-d-Glucoside Inhibits Cellular Energy Production Interacting with HEK2 in Keratinocytes.
    Int J Mol Sci. 2019 May 31;20(11). pii: E2689. doi: 10.3390/ijms20112689. PubMed PMID: 31159225.
  61. Greaves RF, Bernardini S, Ferrari M, Fortina P, Gouget B, Gruson D, Lang T, Loh TP, Morris HA, Park JY, Roessler M, Yin P, Kricka LJ. Key questions about the future of laboratory medicine in the next decade of the 21st century: A report from the IFCC-Emerging Technologies Division.
    Clin Chim Acta. 2019 May 28;495:570-589. doi: 10.1016/j.cca.2019.05.021. [Epub ahead of print] PubMed PMID: 31145895.
  62. Bernardini S, Zima T. Alzheimer’s disease: Making the point.
    Clin Biochem. 2019 May 21. pii: S0009-9120(19)30546-6. doi: 10.1016/j.clinbiochem.2019.05.007.
    [Epub ahead of print] PubMed PMID: 31125534.
  63. Perrone M, Donatucci B, Salvati A, Gualtieri P, De Lorenzo A, Romeo F, Bernardini S.
    Inflammation, oxidative stress and gene expression: the postprandial approach in professional soccer players to reduce the risk of muscle injuries and early atherosclerosis
    Medicina dello Sport 2019 June;72(2):234-43 DOI: 10.23736/S0025-7826.19.03531-2
  64. Perrone MA, Pieri M, Marchei M, Sergi D, Bernardini S, Romeo F. Serum free light chains in patients with ST elevation myocardial infarction (STEMI): A possible correlation with left ventricle dysfunction. Int J Cardiol. 2019 Jun 12. pii: S0167-5273(19)30221-9. doi:10.1016/j.ijcard.2019.06.016. [Epub ahead of print] PubMed PMID: 31253526.
  65. Di Renzo L, Cioccoloni G, Bernardini S, Abenavoli L, Aiello V, Marchetti M, Cammarano A, Alipourfard I, Ceravolo I, Gratteri S. A Hazelnut-Enriched Diet Modulates Oxidative Stress and Inflammation Gene Expression without Weight Gain. Oxid Med Cell Longev. 2019 Jul 4;2019:4683723. doi: 10.1155/2019/4683723. eCollection 2019. PubMed PMID: 31354906; PubMed Central PMCID: PMC6637671.
  66. Krashia P, Cordella A, Nobili A, La Barbera L, Federici M, Leuti A, Campanelli F, Natale G, Marino G, Calabrese V, Vedele F, Ghiglieri V, Picconi B, Di Lazzaro G, Schirinzi T, Sancesario G, Casadei N, Riess O, Bernardini S, Pisani A, Calabresi P, Viscomi MT, Serhan CN, Chiurchiù V, D’Amelio M, Mercuri NB. Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease. Nat Commun. 2019 Sep 2;10(1):3945. doi: 10.1038/s41467-019-11928-w. PubMed PMID: 31477726; PubMed Central PMCID: PMC6718379.
  67. Castaman G, Santoro C, Coppola A, Mancuso ME, Santoro RC, Bernardini S, Pugliese FR, Lubrano R, Golato M, Tripodi A, Rocino A, Santagostino E, ad hoc Working Group 2019.
    Emergency management in patients with hemophilia A and inhibitors on prophylaxis with emicizumab: AICE practical guidance in collaboration with SIBioC, SIMEU, SIMEUP, SIPMeL and SISET.
    Blood Transfusion, 2019; 18: 1-8.
  68. Lattanzi R, Maffei D, Petrella C, Pieri M, Sancesario G, Schirinzi T, Bernardini S, Barbato C, Ralli M, Greco A, Possenti R, Sancesario G, Severini C.
    Involvement of the Chemokine Prokineticin-2 (PROK2) in Alzheimer’s Disease: From Animal Models to the Human Pathology
    Cells. 2019 Nov 13;8(11). pii: E1430. doi: 10.3390/cells8111430.
  69. Diluvio L, Caporali S, Lozzi F, Campione E, Mazzilli S, Lanna C, Bianchi L, Bernardini S, Minieri M, Mauriello A, Ferlosio A, Candi E, Terrinoni A.
    Birt-Hogg-Dubé syndrome, from non-invasive dermatologic assessment to gene
    testing, molecular and ultrastructural histologic analysis.
    J Eur Acad Dermatol Venereol. 2019 Dec 26. doi: 10.1111/jdv.16168. [Epub ahead of
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  70. Bruno V, Nuccetelli M, Ticconi C, Bruno A, Martelli F, Capogna MV, Bernardini S, Piccione E, Pietropolli A.
    Amniotic fluid antiphospholipid antibodies: potential role in antiphospholipid syndrome-independent aberrant implantation process.
    Reprod Biol Endocrinol. 2019 Oct 15;17(1):79. doi: 10.1186/s12958-019-0527-2.
  71. Graziella Calugi, Maria Rosaria De Cagna, Elena Zocca, Maria Teresa Quarantelli, Caterina Iodice, Maria Loredana Frassanito, Alessandra Valentini, Massimo Pieri, Bernardini S (2020). Evaluation and analytical performance of the new Roche T411 and T511 coagulation analysers. THROMBOSIS RESEARCH, vol. 187, p. 166-169, ISSN: 0049-3848, doi: 10.1016/j.thromres.2020.01.018.
  72. Romigi A, Bari M, Liguori C, Izzi F, Rapino C, Nuccetelli M, Battista N, Bernardini S, Centonze D, Mercuri N, Placidi F, Maccarrone M. (2020). SF levels of the endocannabinoid anandamide are reduced in patients with untreated narcolepsy type 1: a pilot study. CNS & NEUROLOGICAL DISORDERS. DRUG TARGETS, ISSN: 1871-5273, doi: 10.2174/1871527319666200309115602
  73. Schirinzi T, Di Lazzaro G, Sancesario GM, Summa S, Petrucci S, Colona VL, Bernardini S, Pierantozzi M, Stefani A, Mercuri NB, Pisani A. (2020). Young-onset and late-onset Parkinson’s disease exhibit a different profile of fluid biomarkers and clinical features.. NEUROBIOLOGY OF AGING, ISSN: 0197-4580, doi: : 10.1016/j.neurobiolaging.2020.02.012